{"data":[{"id":183,"feed_id":{"id":43,"status":"published","date_created":"2024-01-19T17:00:00.000Z","date_updated":"2024-07-06T13:32:02.591Z","promoted":false,"feed_connect":[{"id":35,"collection":"Articles","feed_id":{"id":43,"status":"published","user_created":"0cabeeee-b9f2-4440-ad9c-13e119f68b4c","date_created":"2024-01-19T17:00:00.000Z","user_updated":"0cabeeee-b9f2-4440-ad9c-13e119f68b4c","date_updated":"2024-07-06T13:32:02.591Z","promoted":false,"feed_connect":[35],"feed_tag":[183,184,185,186,187]},"item":{"id":24,"status":"published","date_created":"2024-01-19T14:26:00.000Z","title":"Can Psychedelics Be The Cure For Cocaine Use Disorder","content_body":"

The most recent clinical psychology research from Harvard University's Nock Laboratory in Boston, MA, suggests that classic psychedelics, including peyote, mescaline, psilocybin, and LSD, may be linked to a reduced likelihood of substance misuse and the development of Cocaine Use Disorder (CUD).

Key findings from the study include:

Peyote use is associated with a decrease of over 50% in the odds of developing CUD.
All other classic psychedelics either show no significant changes in the development of CUD or an increased risk.
The study results could contribute to the development of treatment strategies for CUD involving psychedelics.

Classical psychedelics, such as peyote, mescaline, psilocybin, and LSD, have a history documented in medical literature since the 1940s and have been utilized by indigenous cultures for ceremonial, spiritual, and ritualistic purposes for thousands of years. These substances act on the brain by affecting the serotonin 2A receptor, inducing altered visual, auditory, and consciousness states associated with psychedelic experiences.

Previous research has linked classic psychedelic use to the improvement of substance use disorders, including nicotine and alcohol addiction. Recent associations have also been made between psychedelic use and reductions in the abuse of other substances like cannabis, stimulants, and opioids.

While research on the association of classical psychedelics with the relief or prevention of CUD is limited, other studies suggest the potential utility of psychedelics for CUD. For example, the use of ketamine, a non-classical psychedelic, has been linked to reduced cocaine use, cravings, relapse, and increased abstinence. Ketamine acts on the glutamate system, different from the serotonin system targeted by classical psychedelics, but produces similar effects, including mystical experiences associated with improvements in CUD.

To investigate further, researchers at the Nock Laboratory analyzed four years of data from over 214,500 respondents participating in The National Survey on Drug Use and Health (NSDUH). Out of the participants, 1,017 were identified with CUD based on DSM-IV criteria. The study examined whether the use of each classic psychedelic was associated with decreased odds of CUD, and if so, explored which DSM-IV criteria were affected.

Among the classical psychedelics, peyote was the only substance associated with significantly lower odds of CUD in the previous year, with odds reduced by more than 50%. It also showed lowered odds for 7 out of 11 total CUD criteria outlined by DSM-IV.

Peyote was linked to lower odds for 4 out of 7 criteria for cocaine dependence in CUD and 3 out of 4 criteria for cocaine abuse in CUD. As both risk factors and protective factors for CUD are not well understood, these study results could stimulate further discussion in scientific and medical communities.

Future research may provide a deeper understanding of why peyote is associated with decreased CUD and explore the association of other classical psychedelics with increased chances of CUD, as well as reasons why mescaline, despite its similarities to peyote, does not show lowered odds of CUD.

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Magic mushrooms, also known as psilocybin mushrooms, have a long and fascinating history that dates back thousands of years. Indigenous societies, such as the Aztecs of Mexico, considered these mushrooms to be sacred and referred to them as \"God's flesh.\" However, scientific study of psilocybin, the psychoactive component of magic mushrooms, didn't begin until 1957 when Swiss chemist Albert Hoffman isolated the compound. Unfortunately, the recreational use of psychedelics in the 60s led to their stigmatization and illegality, and scientific research was halted.

However, in recent years, there has been a resurgence of interest in studying the therapeutic potential of magic mushrooms. In fact, psilocybin has been granted \"breakthrough therapy\" status for depression by the U.S. Food and Drug Administration, which allows for expedited approval. This has led to a significant increase in clinical trials studying psilocybin and its effects on various mental health conditions.

One prominent researcher in this field is Fred Barrett, a neuroscientist at the Johns Hopkins Center for Psychedelic & Consciousness Research. According to Barrett, psilocybin-assisted psychotherapy has the potential to treat a wide range of mental health conditions, including eating disorders, obsessive-compulsive disorder, anxiety, and chronic pain. While research is still in its early stages, promising results have already been seen. In a 2020 study conducted by Johns Hopkins Medicine, it was found that just two doses of psilocybin, when combined with psychotherapy, led to significant reductions in depression symptoms. These benefits were even effective for up to a year. Another study involving 233 participants across 10 countries demonstrated that a single dose of psilocybin significantly reduced symptoms of depression in individuals for whom other treatments had failed.

Comparatively, traditional antidepressant medications often need to be taken daily and may not work for everyone. Psilocybin has the potential to offer significant relief to those with treatment-resistant mental health conditions. The FDA expects to see large-scale studies involving thousands of participants before granting approval for psilocybin as a pharmaceutical drug.

The therapeutic effects of psilocybin are thought to be attributed to its ability to generate new connections between neurons, thus rebuilding critical pathways that have been lost to mental health disorders. This process is known as brain plasticity and plays a crucial role in learning and adaptation. Additionally, there is growing evidence that psilocybin increases cognitive flexibility and psychological flexibility, allowing individuals to think in different ways and change their perception of themselves and the world around them.

It's important to note that psilocybin-assisted therapy involves a carefully curated process that includes weeks or months of unstructured talk therapy. This helps individuals process and integrate their experiences during the psychedelic session, which can often be intense and emotionally challenging.

In exciting news for the field, the Centre for Addiction and Mental Health (CAMH) in Canada received its first federal grant from the Canadian Institutes of Health Research (CIHR) in July 2022 to study psilocybin. This highlights the growing recognition and support for psychedelic therapies in the medical community.

Furthermore, in December 2022, Quebec became the first governing medical body in Canada to publicly fund medical psilocybin-assisted psychotherapy. This step forward demonstrates the increasing acceptance and acknowledgment of the potential benefits of psychedelic therapies.

As research continues to expand, the potential therapeutic uses of magic mushrooms and psilocybin are becoming increasingly clear. While there are still many hurdles to overcome, the future of psychedelic-assisted therapy looks bright. The healing potential of psilocybin for various mental health conditions is being explored, and the results so far are promising. With further research and larger-scale studies, it is possible that psilocybin could become an approved treatment for depression and other mental health disorders in the near future.

It's an exciting time for the field of psychedelic research, and the potential impact on mental healthcare is immense. As more people become interested in the therapeutic uses of magic mushrooms, it is important to approach the topic with an open mind and a focus on evidence-based research. With continued support and funding, we hope to see further advancements in the understanding and implementation of psilocybin-assisted therapy.

In the meantime, it's important to remember that psilocybin is still considered illegal in many parts of the world. If you are interested in exploring psychedelic therapy, it is crucial to do so legally and under the guidance of trained professionals in a controlled and safe environment.

Overall, the therapeutic uses of magic mushrooms hold great promise for the future of mental healthcare. As research progresses and more is understood about their potential benefits, we can hope to see greater acceptance and accessibility of psilocybin-assisted therapy for those in need.

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